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Koutaro Yokote Selected Research

Werner Syndrome (Werner's Syndrome)

1/2022A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency.
2/2021Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome.
12/2020Evaluation of glucose tolerance and effect of dietary management on increased visceral fat in a patient with Werner syndrome.
11/2019NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
11/2019Investigator-initiated clinical study of a functional peptide, SR-0379, for limb ulcers of patients with Werner syndrome as a pilot study.
1/2018RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.
3/2016Improved Glycemic Control and Vascular Function and Reduction of Abdominal Fat Accumulation with Liraglutide in a Case of Werner Syndrome with Diabetes Mellitus.
6/2015Astaxanthin Improves Nonalcoholic Fatty Liver Disease in Werner Syndrome with Diabetes Mellitus.
3/2014Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas.
8/2013Sitagliptin improves postprandial hyperglycemia by inhibiting glucagon secretion in Werner syndrome with diabetes.
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Koutaro Yokote Research Topics

Disease

22Type 2 Diabetes Mellitus (MODY)
01/2022 - 06/2009
19Neoplasms (Cancer)
06/2021 - 04/2009
19Atherosclerosis
01/2021 - 01/2003
18Diabetes Mellitus
05/2022 - 07/2009
18Werner Syndrome (Werner's Syndrome)
01/2022 - 09/2004
13Dyslipidemias (Dyslipidemia)
09/2021 - 01/2012
11Body Weight (Weight, Body)
01/2022 - 12/2008
8Obesity
01/2022 - 04/2011
8Cardiovascular Diseases (Cardiovascular Disease)
09/2021 - 10/2009
7Hypoglycemia (Reactive Hypoglycemia)
11/2021 - 01/2010
7Hyperglycemia
07/2020 - 03/2012
6Inflammation (Inflammations)
01/2022 - 04/2004
6Ulcer
12/2021 - 06/2012
6Hypertriglyceridemia
01/2021 - 01/2018
6Hypercholesterolemia
05/2019 - 12/2008
6Drug-Related Side Effects and Adverse Reactions
06/2018 - 01/2016
6Diabetic Nephropathies (Diabetic Nephropathy)
04/2016 - 03/2005
5Weight Loss (Weight Reduction)
01/2022 - 11/2019
5Insulin Resistance
02/2020 - 01/2008
5Coronary Artery Disease (Coronary Atherosclerosis)
01/2019 - 01/2012
4Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)
08/2022 - 01/2016
4Macular Edema
05/2022 - 03/2014
4Hypertension (High Blood Pressure)
12/2021 - 03/2005
4Inborn Genetic Diseases (Disease, Hereditary)
10/2021 - 01/2012
4Adenoma (Adenomas)
06/2021 - 09/2017
4Infections
02/2021 - 01/2015
4Transient Ischemic Attack
01/2021 - 01/2018
4Chronic Renal Insufficiency
01/2021 - 06/2010
4Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
05/2019 - 01/2012
4Xanthomatosis (Xanthoma)
08/2018 - 01/2012
4Myocardial Ischemia (Ischemic Heart Diseases)
12/2014 - 07/2009
3Rheumatoid Arthritis
01/2022 - 11/2016
3Osteoarthritis
01/2022 - 06/2015
3Skin Ulcer
12/2021 - 01/2018
3Diabetic Retinopathy (Retinopathy, Diabetic)
07/2021 - 01/2018
3Pain (Aches)
02/2021 - 05/2010
3Ischemic Stroke
01/2021 - 12/2020
3Esophageal Squamous Cell Carcinoma
01/2021 - 10/2020
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2021 - 01/2014
3Albuminuria
01/2021 - 06/2003
3Type 1 Diabetes Mellitus (Autoimmune Diabetes)
06/2019 - 07/2006
3Stroke (Strokes)
01/2019 - 07/2009
3Cerebral Infarction
02/2018 - 01/2016
3Osteoporosis
11/2017 - 01/2012
3Leukemia
04/2014 - 02/2012
2Pituitary ACTH Hypersecretion
11/2022 - 09/2017

Drug/Important Bio-Agent (IBA)

21Glucose (Dextrose)FDA LinkGeneric
05/2022 - 06/2009
18Proteins (Proteins, Gene)FDA Link
07/2022 - 04/2009
16LipidsIBA
07/2022 - 12/2008
12Insulin (Novolin)FDA Link
08/2022 - 01/2010
12oxidized low density lipoproteinIBA
11/2019 - 02/2008
11(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA
09/2021 - 01/2018
10LDL CholesterolIBA
09/2021 - 01/2012
9SodiumIBA
05/2022 - 05/2010
9Triglycerides (Triacylglycerol)IBA
12/2021 - 06/2014
9Biomarkers (Surrogate Marker)IBA
01/2021 - 10/2013
8Pharmaceutical PreparationsIBA
01/2022 - 12/2008
8Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
11/2019 - 06/2009
7HDL CholesterolIBA
07/2022 - 07/2009
7Blood Glucose (Blood Sugar)IBA
12/2021 - 11/2015
7Sitagliptin Phosphate (Januvia)FDA Link
02/2021 - 12/2012
7CholesterolIBA
09/2018 - 07/2009
6ipragliflozinIBA
02/2021 - 01/2016
6AntibodiesIBA
01/2021 - 01/2018
5Hormones (Hormone)IBA
08/2022 - 03/2016
5DNA (Deoxyribonucleic Acid)IBA
01/2022 - 04/2009
5Lipoproteins (Lipoprotein)IBA
09/2021 - 09/2013
5Hypoglycemic Agents (Hypoglycemics)IBA
07/2021 - 11/2012
5AntigensIBA
01/2021 - 10/2020
5Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
11/2019 - 01/2016
5Messenger RNA (mRNA)IBA
01/2018 - 01/2010
5Pioglitazone (Actos)FDA Link
05/2015 - 09/2004
4Hydrocortisone (Cortisol)FDA LinkGeneric
11/2022 - 10/2015
4DNA HelicasesIBA
01/2022 - 08/2008
4EnzymesIBA
07/2021 - 09/2013
4RNA (Ribonucleic Acid)IBA
06/2021 - 08/2011
4Metformin (Glucophage)FDA LinkGeneric
02/2021 - 01/2017
4Peptides (Polypeptides)IBA
01/2021 - 01/2018
4Sodium-Glucose Transporter 2 InhibitorsIBA
01/2021 - 01/2017
4Complementary DNA (cDNA)IBA
01/2021 - 10/2020
4pitavastatin (itavastatin)FDA Link
05/2011 - 12/2008
4Transforming Growth Factor beta (TGF-beta)IBA
04/2009 - 04/2005
3Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA
08/2022 - 01/2016
3Methotrexate (Mexate)FDA LinkGeneric
01/2022 - 07/2021
3GlucocorticoidsIBA
12/2021 - 03/2016
3ImmunosorbentsIBA
01/2021 - 10/2020
3Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2021 - 01/2018
3Immunoglobulin G (IgG)IBA
01/2021 - 10/2020
3TabletsIBA
01/2020 - 10/2009
3Fenofibrate (CiL)FDA LinkGeneric
06/2018 - 01/2016
3Phosphotransferases (Kinase)IBA
08/2015 - 04/2009
3Superoxides (Superoxide)IBA
06/2015 - 01/2014
3Atorvastatin (Lipitor)FDA Link
06/2015 - 12/2008
3Transforming Growth Factors (Transforming Growth Factor)IBA
04/2011 - 04/2005

Therapy/Procedure

17Therapeutics
07/2021 - 10/2011
10Glycemic Control
11/2021 - 10/2011
5Bariatric Surgery
01/2022 - 04/2015
5Aftercare (After-Treatment)
01/2022 - 01/2015
4Gastrectomy
01/2022 - 11/2017
4Drug Therapy (Chemotherapy)
07/2021 - 02/2012